Hormones that are non-Bio-Identical use a one-size-fits-all approach to hormone therapy with hormones that are foreign to a woman’s body. We cannot generalize these study results to all estrogens. Conversely, Bio-Identical hormones, which are the same as what is in your body naturally, have been proven to be safe. As far as heart disease, Bio-Identical hormone therapy has never been shown to increase the risk of heart disease. As a matter of fact, hormone replacement with Bio-Identical hormones has been shown to decrease the risk of heart disease.